GHK-Cu

GHK-Cu — Research Profile

Compound Overview

Scientific Background

GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper) is a naturally occurring tripeptide first identified in human plasma. It forms a stable complex with copper (II) ions and has been the subject of extensive research across dermatology, wound healing, and anti-aging biology. GHK-Cu levels decline significantly with age, which has driven substantial interest in its role in tissue maintenance and regenerative signalling.

Research suggests GHK-Cu modulates gene expression across hundreds of biological pathways, including those involved in collagen synthesis, antioxidant defence, inflammation regulation, and stem cell activation. It is one of the most studied peptides in skin biology and regenerative research.

Research Areas

Skin Biology & Wound Healing

GHK-Cu is extensively studied for its effects on dermal fibroblast activity, collagen and elastin production, and wound contraction. Preclinical models have demonstrated accelerated wound closure and improved skin tensile strength following GHK-Cu application.

Anti-Aging & Tissue Remodelling

Research has shown GHK-Cu influences the activity of matrix metalloproteinases (MMPs) and their inhibitors, playing a role in balanced extracellular matrix remodelling. Studies have also investigated its potential to reverse age-related gene expression patterns in human fibroblasts.

Antioxidant & Anti-Inflammatory Activity

GHK-Cu has demonstrated superoxide dismutase-like activity in research models, suggesting a role in reducing oxidative stress. It has also been studied for modulation of pro-inflammatory cytokines including TNF-α and IL-6.

Hair Follicle Research

Preclinical studies have investigated GHK-Cu’s effects on hair follicle size, follicle proliferation, and hair growth cycles, with findings suggesting potential relevance to alopecia research.

Quality & Testing

• Purity ≥98% confirmed by reverse-phase HPLC
• Identity verified by mass spectrometry
• Endotoxin tested (<0.1 EU/mg)
• Supplied as sterile lyophilised powder

Disclaimer

This product is intended for in vitro research and laboratory use only. It is not intended for human or veterinary use, nor for diagnostic, therapeutic, or cosmetic applications. By purchasing, you confirm that you are a qualified researcher with appropriate facilities and that the compound will be used solely for lawful scientific research purposes in accordance with applicable regulations.

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